The best choice compression ratio of S2 versus Huffman is 1.0 or no compression at all! Although VwlDrp compression achieves a high compression ratio, it is lossy (pity the poor frog that has to make proteins out of that compressed DNA!). Our simple version of Lempel Ziv is going to get into trouble with such a long sequence, but let's ignore that; calculating a compression ratio is still going to be challenging, as the compressed Lempel Ziv uses more than 4 symbol types (therefore we can't compare it directly to the source message, nor can we use S2 to convert both to binary). In any case, it is definitely possible to calculate compression ratios for Huffman and VwlDrp, and decide which one is best.